* With patients with reduced liver or kidney function caution is required. * So far only patients were treated, who were younger than 75 years. * Patients with Laktoseintoleranz may not take the medicine, since it contains Laktose. * So far patients were treated maximally two years, possible long-term effects are unknown therefore. * Patients with fresh cardiac infarct or impact accumulation (less than six months) were not examined.